PKRRATING OPTIONS

The activated enzyme then phosphorylates its big substrate, the translational initiation variable eIF2α. The ensuing translational arrest blocks viral replication. PKR belongs into a conserved loved ones of 4 protein kinases (PKR, PERK, GCN2, HRI) that all phosphorylate eIF2α in reaction to diverse stimuli12, triggering the built-in stress respon